ICsense is ISO13485 certified for medical ASIC developments. For over 10 years, the mixed-signal ASICs of ICsense are used in implantable class III medical devices, ultra-low-power devices with enhanced battery life, hearing aid devices and wearables/portables for renowned medical device manufacturers.
Through its systematic and certified development process, ICsense can ensure the quality, safety and long-term reliability for medical ASICs.
Our approach in medical ASIC developments
- ISO 13485:2012 certified for design, development and production
- Ultra-low-power in combination with high-voltage for long battery life
- Minimization of external components for minimal device size
- MRI / EMC / ESD compatibility
- Hazard and risk management: HARA, FMEA, …
- Support of FDA and CE marking process
- X-ray imaging chipset
- Ultrasonic TX/RX
- Power management chip
- Deep brain stimulator
- Li-ion Battery charger
- Nerve stimulation IC
- Hearing aid power mgmt
- Lab-on-chip interface
- ECG readout
- Wireless power/data transfer
This fully-programmable medical qualified ASIC serves applications such as nerve stimulation, spinal cord stimulation, Deep Brain Stimulation (DBS), … . It contains 10 stateof-the-art pulse-generators, a 40-channel high-voltage MUX and 10 differential sensing channels.
- Fully programmable pulses, through 10 PG (Pulse Generators):
- V = +3V .. -15V
- I = 0 .. 6.5mA
- T = 0 .. 10ms
- 10 PGs can be muxed over 40 channels
- 10 differential sensing channels (I-amp, CT delta-sigma ADC)
- Power management containing:
- Full bridge rectification
- Inverting DC-DC
- Charge pumps
- MRI clamps to keep all blocks in SOA (Safe Operating Area) during MRI field exposure
- High-efficient AC power transfer between IPG and ASIC (DC-AC-DC conversion)
- High performance stimulation and neutralisation DACs
- 0.35u BCD
- Area: 3.9 mm x 8.0 mm
The battery operated ASIC is the main part of a new generation wearable electronic reminder system for timely medication intake, producing mild electronic pulses to the patient.
It contains a highly accurate fully integrated on-chip clock, a power generation block consisting of a DC-DC converter and a high-voltage driver, and a programming unit to program the timing, voltage, power and shape of the applied pulses.
- 1000ppm low-power (uWs) on-chip timer without crystal or any other external components
- Power generation duty cycling
- ASIC, electronics, battery, communication in one patch: minimal BOM
- High-voltage (up to 35V), high-power pulse bursts generated from a single button cell battery
- Programmable pulse shapes, timings, …
- 0.35um 50V BCD
The low-power low-noise ASIC includes 3 differential bio-potential channels and one bio-impedance measurement channel to measure body impedance variation due to respiration.
Fully configurable digital filtering and processing blocks and lead-off check and pacemaker detection blocks are also embedded in the ASIC, together with right leg driver, shield driver and Wilson common terminal blocks, making it ideal for (battery-operated) ECG systems.
- 3 differential bio-potential channels (up to 10 kHz)
- 1 body-impedance measurement channel
- embedded pacemaker pulse detection
- fully integrated high-pass filter to remove half-cell DC values (0.6V)
- 5uV absolute accuracy @ mV input-range
- low supply voltage: 1.62 V to 3.6 V
- maximum flexibility due to input connection circuit matrix
- configurable band-pass filters
- IQ impedance demodulation
- DC and AC lead-off detection
- Right leg driver (RLD), low 1/f-noise Wilson common terminal (WCT) and shield driver (SD)
- Less than 1 mA/channel at maximum bandwidth and maximum resolution
- SPI daisy chain to connect 4 ICs in parallel
- EMI tolerant
- 6x6mm 40-lead LGA
- 0.13um CMOS
ICsense has implemented direct nerve stimulation electrode arrays and nerve response telemetry for cochlear implants.
The key challenge was to deliver an accurate charge to the tissue and be able to measure identical charges from the tissue. As the electronics are wirelessly powered, low power consumption is crucial. The response of the nerves and brain is measured using high-voltage, high-accuracy and low power instrumentation amplifiers.
- High-voltage, ultra-low-power
- Accurate charge delivery: highly-accurate DACs with fast settling and fast transients
- High inter-electrode matching
- Nerve and brain response instrumentation: uV rms noise and offset with high-voltage inputs, high gain
- Low standby current
- 0.35um BCD 80V technology
This ASIC is part of an Implantable Neuro Stimulator (INS) system with 24 amplitude independent channels. The ASIC powers all components of the IPG system and charges the internal battery.
The ASIC can draw its power from any primary battery, rechargeable Li-Ion batteries or wireless power transfer. Li-Ion batteries are charged through a proprietary inductive wireless power link. To ensure a long battery life, the Li-Ion charging is highly accurate up to 0.1% and peak currents are minimized.
- Intelligent wireless power transfer and power rectification
- Inductive buck/boost DC-DC converter
- Li-Ion battery charge controller
- Battery peak current minimization and accurate charging (<10mV) for long lifetime
- Battery state monitoring (fuel gauge, temperature, …)
- Safety: under/overvoltage, over-temperature protection
- Sleep mode: 150nA (POR, clock, controller)
- Storage mode: 7nA ( much lower than the self-discharge of battery)
- 0.5um CMOS technology
This medical lab-on-chip ASIC was designed as part of a disposable apparatus for tumor cell detection. The goal is to detect and characterize cancer tumor cells in blood in only a few hours.
To achieve this, tumor cells are extracted from the blood and put through an active sieve. ICsense developed the ASIC that does electrical cell impedance spectroscopy on all sieve holes to count the cells and determine the cell real and imaginary impedances. The read-out consists of all signal processing of the current through the measured impedance for every frequency to a digital output (I-to-V conversion, programmable amplification, filtering and analog-to-digital conversion).
- Fast and low-cost occult tumor cell detection in blood
- Active silicon sieve with 10000 pores
- Cell impedance spectroscopy 10kHz to 1 MHz
- Electrolysis of cells to extract mRNA
- 10 bit band-pass delta-sigma ADC
- 4th-order, 30kHz pass band around 10k-1MHz
- Intrinsic IQ demodulation
- 0.18um BCD (32V)
“This project has received funding from the European Union’s Seventh Programme for research, technological development and demonstration under grant agreement No 257743.” – http://www.miracle-fp7.eu
The power management ASIC is developed for battery powered implanted hearing aids. The ASIC converts the power of both single or stacked ZnO2 or Li-Ion batteries.
The high-efficient energy conversion is required to power the audio capture chain including ADC, a class D audio driver chain and the digital audio processing. It also manages the inductive communication between the hearing aid and the implant.
- Versatile high-efficiency buck/boost DC-DC converter
- Audio capture chain (amps and 12-bit ADC)
- Audio quality class D output driver
- Battery safety features and low leakage
- Low power consumption
- 0.18um CMOS technology
The chipset is developed for large-scale, portable X-ray applications for a-Si backplanes. It consists of a high-voltage row-driver ASIC that controls the TFT pixels and a low-noise, column readout ASIC that reads the charges from the pixels.
The chipset achieves state-of-the-art noise levels with much lower power consumption and cost. The chips are assembled on the glass panel using chip-on-glass flip-chip technology with ACF. The ASICs are currently used in commercial X-ray imagers.
- Static mode: 1 fps/ 14-bit/ 2.8 noise counts
- Dynamic mode: 5 fps/ 4.4 noise counts (binning)
- ROIC: 16 x 14-bit ADCs at 200kS/s, high-speed LVDS
- Rows: 3456 / Columns: 2880: 10Mpixel
- Chip on glass X-ray panel (Flip-chip, RDL)
- High ball count: 216 I/Os per ASIC
- 0.18um BCD technology
The ASIC is part of a novel DBS system with at least 40 electrodes for steering brain stimulation and brain recording. The ASIC is close to the electrodes, not part of the IPG/INS.
For safety, AC power is transferred to the ASIC through a dedicated DC-AC-DC conversion scheme over the lead cable together with the data. ASIC power consumption is extremely minimized for battery life. The ASIC distributes the stimulation currents to the electrodes with a high compliance voltage. In addition, the ASIC records up to 10 electrodes and can measure the brain impedance (patented). The ASIC is EMC and MRI compatible.
- AC power transfer between IPG and ASIC is based on DC-AC-DC conversion
- High-voltage pulse stimulation on 40-electrodes through a high-voltage switch matrix
- 10 differential sensing channels to record small neurological brain signals (0.1mV – 10mV)
- Ultra-low-power of only 15 uA in stimulation mode
- Recording mode current consumption <10uA
- On-chip brain impedance measurement
- MRI / EMC / ESD compatible
- 0.35um 50V BCD technology