Impedance spectroscopy ASIC for cancer cell detection and characterization
This medical lab-on-chip ASIC was designed as part of a disposable apparatus for tumor cell detection. The goal is to detect and characterise cancer tumor cells in blood in only a few hours. To achieve this, tumor cells are extracted from the blood and put through an active sieve. The ASIC performs electrical cell impedance spectroscopy on all sieve holes to count the cells and determine the cell real and imaginary impedances. The read-out consists of all signal processing of the current through the measured impedance for every frequency to a digital output (I-to-V conversion, programmable amplification, filtering and analog-to-digital conversion).
FEATURES
Fast and low-cost occult tumor cell detection in blood
Active silicon sieve with 10000 pores
Cell impedance spectroscopy 10kHz to 1 MHz
Electrolysis of cells to extract mRNA
10 bit band-pass delta-sigma ADC
4th-order, 30kHz pass band around 10k-1MHz
Intrinsic IQ demodulation
0.18um BCD (32V)
REFERENCES
“This project has received funding from the European Union’s Seventh Programme for research, technological development and demonstration under grant agreement No 257743.”
Why choose ICsense for your next medical ASIC development ?
ICsense is ISO13485 certified for medical ASIC developments. Since 2004, the mixed-signal ASICs of ICsense are used in implantable class III medical devices, ultra-low-power devices with high sensing accuracy, hearing aid devices and wearables/portables for world-class medical device manufacturers. Through its systematic and certified development process, ICsense can ensure the quality, safety and long-term reliability for medical ASICs.
Our values:
Over +20 years of expertise in medical ASIC design
Exclusive development and supply. IP owned by the customer
ISO13485 certified for medical IC designs (implants + external)
